
Stay close to everything while enjoying the comfort and privacy of your own Key West home.
Casa Mamisa is a beautifully appointed two bedroom home tucked along a quiet lane just off Duval Street in historic Old Town. Restaurants, galleries, shopping, beaches, bars and Key West's most beloved attractions are all within easy walking distance, yet the home itself feels wonderfully removed from the bustle of the island.
Inside, an open living and kitchen area creates an inviting place to gather, while two comfortable bedrooms give everyone room to settle in. Step outside from the primary suite and you'll find a private backyard with a porch swing and grill, creating a peaceful outdoor space to enjoy the warm Key West evenings.
And with free on premises parking, Casa Mamisa offers something particularly valuable in Old Town: the convenience of having a car when you need it without having to give up a walkable location.


-Vanessa, July 2026
Casa Mamisa is just a short walk from Duval Street's restaurants, galleries, boutiques and nightlife, yet tucked along a quiet lane where you can relax in peace.
Explore Old Town, visit the beach, then return home to grill dinner and unwind on the porch swing. It's the best of Old Town without the bustle.
Duval Street
2 minute walk
Local Dining & Shopping
2-15 minute walk
Hemingway Home
7 minute walk
Fort Zachary Taylor Beach
12 minute walk
Live Music & Nightlife
2 minute walk


Casa Mamisa gives you the convenience of being close to Duval Street without putting you directly in the middle of its noise and activity. It's an easy walk to the best of Old Town, followed by a peaceful retreat when you're ready to relax.

With two bedrooms, two bathrooms, a spacious living area and private outdoor space, Casa Mamisa gives everyone room to settle in. It's especially comfortable for families, two couples or friends traveling together.

We're a locally based Key West team and we're here to help throughout your stay. Whether you need a restaurant recommendation, directions to the beach or advice on what to do on a rainy afternoon, we're happy to share our local knowledge.
Casa Mamisa combines the comfort of a private home with the thoughtful amenities that make settling into Key West simple.
One dog is welcome with advance approval.
A $200 pet fee applies and there is no weight limit. Dogs must be crated when left alone and may not bark or disturb neighbors. Guests are responsible for cleaning up after their pets both inside and outside.
Because the home has wood floors, guests traveling with pets should use a tray beneath food and water bowls and ensure dogs' nails are trimmed and filed before arrival.
Please contact us before booking if you plan to bring your dog.
Casa Mamisa offers a more peaceful way to experience Key West, combining the convenience of a vacation rental near Duval Street with the privacy and comfort of a beautifully appointed Old Town home. From this quiet lane just off Duval, guests can walk to the island’s celebrated restaurants, galleries, boutiques, historic landmarks, beaches and waterfront attractions, then return to a private retreat away from the busiest streets.
Begin the morning in the open kitchen and living area with a freshly brewed cup of coffee before setting out to explore historic Old Town Key West. Spend the day browsing galleries and boutiques along Duval Street, visiting the Ernest Hemingway Home and Museum, climbing the Key West Lighthouse or enjoying lunch at one of the many nearby restaurants. In the afternoon, continue toward Higgs Beach, the historic seaport or Mallory Square, all while enjoying the freedom of having so many of Key West’s most popular destinations within easy reach.
When you are ready to relax, Casa Mamisa is only a comfortable walk away. Return to the cool, inviting interior, stretch out on the plush sectional and enjoy the oversized Smart TV, or prepare dinner in the well-equipped kitchen using the essentials provided for a comfortable stay. As evening settles over the island, step into the private backyard, relax on the porch swing or gather around the Weber grill for an unhurried dinner at home.
For travelers searching for a Key West vacation rental near Duval Street, Casa Mamisa offers an appealing balance of walkable location, residential privacy and everyday comfort. The home is close enough to place the best of Old Town within easy walking distance, while its quiet setting provides a welcome retreat after a day of sightseeing, dining and exploring.
With two bedrooms and two full bathrooms, Casa Mamisa is well suited to families, couples traveling together and friends sharing a Key West getaway. The primary suite features a king bed, an en suite bathroom with a walk-in shower and direct access to private outdoor space. The second bedroom includes a queen bed, while the living room sofa bed provides additional sleeping space for up to six guests.
This thoughtful layout allows everyone to enjoy the convenience of a shared vacation home while maintaining the privacy and flexibility that make a longer stay especially comfortable. With a full kitchen, central air conditioning, private laundry, fast WiFi and inviting indoor and outdoor living areas, Casa Mamisa provides the amenities guests need to settle into Key West with ease.
One of Casa Mamisa’s most valuable advantages is the combination of a walkable Old Town location and free on-premises parking. Guests can leave the car at home while exploring Duval Street, nearby restaurants, historic attractions and the waterfront on foot, then enjoy the added flexibility of having convenient parking available whenever they want to visit another part of the island.
For guests seeking a Key West vacation rental with parking, this feature offers an important level of convenience that can be difficult to find in historic Old Town. Whether you are planning a day at Fort Zachary Taylor Historic State Park, exploring the beaches beyond the immediate neighborhood or simply arriving with a car, Casa Mamisa makes it easy to enjoy the freedom of a private vacation home without giving up proximity to everything that makes Key West special.
After a full day exploring Key West, Casa Mamisa offers a comfortable and private place to return. Cool central air conditioning creates a welcome respite from the tropical afternoon, while the inviting living room provides space to relax, read or gather together. The well-equipped kitchen makes it simple to prepare a casual breakfast or dinner, and the private backyard offers a peaceful setting for enjoying the island’s warm evenings.
Here, you can experience the energy of Duval Street, the character of historic Old Town and the beauty of Key West, then retreat to a home that feels calm, comfortable and distinctly your own. Casa Mamisa places you close to the action without requiring you to live in the middle of it, making it an ideal choice for travelers looking for a peaceful Old Town Key West vacation rental near Duval Street.
Experience Old Town Key West at your own pace, with Casa Mamisa as your comfortable home base.
We would be delighted to welcome you home.
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